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pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can cut down panobinostat ranges by ~70% and produce procedure failure.pentobarbital will reduce the extent or impact of terbinafine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warnin